Pancreatic Islets as a Target of Adipokines.

TitlePancreatic Islets as a Target of Adipokines.
Publication TypeJournal Article
Year of Publication2022
AuthorsReiterer, M, Gilani, A, Lo, JC
JournalCompr Physiol
Date Published2022 Aug 11
KeywordsAdipocytes, Adipokines, Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Insulin-Secreting Cells

Rising rates of obesity are intricately tied to the type 2 diabetes epidemic. The adipose tissues can play a central role in protection against or triggering metabolic diseases through the secretion of adipokines. Many adipokines may improve peripheral insulin sensitivity through a variety of mechanisms, thereby indirectly reducing the strain on beta cells and thus improving their viability and functionality. Such effects will not be the focus of this article. Rather, we will focus on adipocyte-secreted molecules that have a direct effect on pancreatic islets. By their nature, adipokines represent potential druggable targets that can reach the islets and improve beta-cell function or preserve beta cells in the face of metabolic stress. © 2022 American Physiological Society. Compr Physiol 12:1-27, 2022.

Alternate JournalCompr Physiol
PubMed ID35950650