Cardiovascular Research Institute

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CVRI In the News

Sinden's Manuscript to be published in FASEB Journal

CVRI congratulates Daniel Sinden on acceptance of his manuscript: “Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity” in FASEB Journal. Sinden's manuscript will be published in August 2019. 

Daniel Sinden, M.D., Ph.D., to Start his Residency at Massachusetts General Hospital

Daniel Sinden, former visiting M.D, Ph.D student in the Pitt Laboratory, graduated from the Duke Medical Scientist Training Program (MSTP), last May 2019. Daniel’s thesis focused on Fibroblast Growth Factor 13 Regulation of Thermogenesis and Metabolism. Daniel is now moving to Boston to start his Internal Medicine residency at Massachusetts General Hospital. Congratulations Dr. Sinden!


Yasin Hussain, M.D., Won Second Place Prize for the David E. Rogers Memorial Research

Congratulations to Yasin Hussain, M.D., who received second place prize for the David E. Rogers Memorial Research Award. Dr. Hussain was awarded this honor for his research during his medical residency at NewYork-Presbyterian/ Weill Cornell Medicine on the contribution of Cav1.2 Voltage-Gated Calcium Channels to Calcific Aortic Stenosis. Dr. Hussain was mentored by Pitt Lab Post-Doctoral Associate Dr. Maiko Matsui.

Chike Cao, Ph.D., Received a Third Percentile Ranking on her NIH R21 Grant Application

Congratulations to Chike Cao, Ph.D. for receiving a 3%ile Ranking on her NIH R21 Grant Application titled “Regulation of tendon formation by Ca2+ signaling through CaV1.2 L-type voltage-gated calcium channel”.

Chike Cao, Ph.D., published manuscript that provides insight into potential pathological mechanisms underlying perturbed OPG expression and otosclerosis

Pitt Lab Instructor of Medicine Chike Cao, Ph.D., recently published a manuscript “The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear.” The discovery was made after Dr. Cao and her team drove expression of a gain-of-function CaV1.2 mutant channel to target osteochondral/osteoblast progenitors in the auditory ossicles and the oticcapsule.  The mutant mice displayed osteopetrosis of these bones, findings similar to phenotypes seen in mice with an osteoclast defect. The mice displayed hearing loss and defects of body balance in behavior tests, confirming that the CaV1.2-dependent Ca2+ influx affects bone structure in the ear and vestibular functions. These data provide insight into potential pathological mechanisms under-lying perturbed OPG expression and otosclerosis.

Congratulations Dr. Cao!

The Pitt Lab to Welcome Two Awarded Weill Cornell Medical Students During the Summer

The Pitt Lab is pleased to announce that it will welcome two Weill Cornell University medical students during the summer of 2019.

Neil Kelly, Ph.D., was awarded the Glorney-Raisbeck Medical Student Grant in Cardiovascular Disease Research to work in Dr. Geoffrey Pitt’s laboratory; and Radhika Ghosalkar was granted the Atkins Scholarship for summer research to work at the same laboratory. 

Both Neil and Radhika, are first year medical students at Weill Cornell Medical College with an interest in cardiology research.

The Pitt Lab team looks forward to working with Neil and Radhika, and congratulates them for the well-deserved awards.


Jingli Cao, Ph.D., to Join Our CVRI Faculty

The CVRI is pleased to announce that Jingli Cao, Ph.D. will join the CVRI faculty on October 1, 2018.

Dr. Cao’s laboratory will focus on cardiac regeneration, and build upon his paradigm-changing work performed while a postdoctoral fellow in lab of Ken Poss at Duke University. Using the zebrafish model, Dr. Cao developed a powerful explant system and showed that the epicardium is critical in the cardiac regeneration process.

He recently received a prestigious American Heart Association Career Development Award to support his pioneering research in the CVRI. Before joining the Poss lab, Dr. Cao received his PhD from the Shanghai Institute of Biochemistry and Cell Biology. Dr. Cao’s primary appointment will be in the Department of Cell & Developmental Biology at Weill Cornell Medicine.

Pitt Lab Discovers a Gene Mutation That May Lead to a New Osteoporosis Treatment

Chike Cao, Ph.D., a member of the Pitt Laboratory, determined that a gene mutation that affects a voltage-gated Ca2+ channel protein, can increase bone density. In her recent study published in JCI Insight, Cao reveals that expressing the mutant channel increases the normal production of bone-making cells. The discovery opens up the possibility to design new drugs to prevent or reverse osteoporosis

Dr. Geoffrey Pitt Leads Institute Designed to Translate Research Discoveries in Cardiovascular Disease from Bench to Bedside

Originally published in Weill Cornell Medicine Newsroom

NEW YORK (April 29, 2016) — With the goal of improving heart health for patients worldwide, Weill Cornell Medicine has established the Cardiovascular Research Institute to expand and enhance the institution's basic and translational research activities. Dr. Geoffrey Pitt, a leading cardiologist and scientist, will direct the institute, which will be dedicated to understanding the molecular, cellular and genetic underpinnings of the disease.

Headquartered in the Belfer Research Building, the interdisciplinary Cardiovascular Research Institute will build upon the successes of Weill Cornell Medicine's already robust cardiovascular research activities while unifying them under one research entity. Dr. Pitt will recruit a team of leading scientists to the institute to pursue innovative research that improves treatments and therapies for conditions including coronary artery disease, heart failure, cardiac arrhythmias, and hypertension. Read More

Maiko Matsui, Ph.D., Awarded with the Prestigious American Heart Association Postdoctoral Fellowship

New York, June 20, 2017

 Dr. Maiko Matsui, Postdoctoral Associate at the Weill Cornell Medicine’s Pitt Laboratory, was awarded with the prestigious American Heart Association (AHA) Postdoctoral Fellowship Award with the project “Investigating the Contribution of L-Type Calcium Channel Ca V 1.2 in Calcific Aortic Valve Stenosis.”

 Geoffrey Pitt, M.D., Ph.D., Primary Investigator at the Pitt Lab and Cardiovascular Research Institute (CVRI) Director at WCM, is Dr. Matsui’s mentor during her two-year fellowship, which kicks off on July 1st.

 The newly funded award seeks to empower postdoctoral trainees in cardiovascular and stroke research. 

 Congratulations Dr. Matsui!

Weill Cornell Medicine Cardiovascular Research Institute 413 East 69th Street, Belfer Research Building, 5th Floor, New York, NY New York, NY 10021 Phone: 646-962-8429