Faculty

Ion channel disorders ("Channelopathies")

The primary focus of the James C. Lo Lab is to investigate the molecular mechanisms of cardiometabolic diseases with the ultimate goal of developing novel treatments directed against them.

We utilize novel imaging techniques in zebrafish genetic models to dissect the cues driving vascularization and vascular mediation of heart regeneration at the tissue and molecular level.

Persons living with HIV have an increased risk of cardiovascular disease. Our lab studies the links between HIV immune dysfunction and pathogenic mechanisms underlying cardiovascular system complications among people with HIV and receiving virally suppressive antiretroviral therapy.

Using zebrafish as a model, the Cao Lab aims at dissecting how natural heart regeneration is regulated at the cellular and molecular level, and how the generalizable findings can be applied in other regenerative contexts

The Long lab studies the crosstalk between RNA and chromatin, with a focus in stem cell differentiation and cardiac development. This includes understanding the molecular mechanism of RNA-mediated regulation pathways by Polycomb group (PcG) and Trithorax group (TrxG) proteins, RNA-mediated epigenetic regulation of cardiac development, and how epitranscriptomics and epigenetics interconnect.