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Covering and Re-Covering the Heart: Development and Regeneration of the Epicardium.

TitleCovering and Re-Covering the Heart: Development and Regeneration of the Epicardium.
Publication TypeJournal Article
Year of Publication2018
AuthorsCao, Y, Cao, J
JournalJ Cardiovasc Dev Dis
Volume6
Issue1
Date Published2018 Dec 24
ISSN2308-3425
Abstract

The epicardium, a mesothelial layer that envelops vertebrate hearts, has become a therapeutic target in cardiac repair strategies because of its vital role in heart development and cardiac injury response. Epicardial cells serve as a progenitor cell source and signaling center during both heart development and regeneration. The importance of the epicardium in cardiac repair strategies has been reemphasized by recent progress regarding its requirement for heart regeneration in zebrafish, and by the ability of patches with epicardial factors to restore cardiac function following myocardial infarction in mammals. The live surveillance of epicardial development and regeneration using zebrafish has provided new insights into this topic. In this review, we provide updated knowledge about epicardial development and regeneration.

DOI10.3390/jcdd6010003
Alternate JournalJ Cardiovasc Dev Dis
PubMed ID30586891
Grant List18CDA34110108 / / American Heart Association /