Title | Boron Chemicals in Drug Discovery and Development: Synthesis and Medicinal Perspective. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Das, BC, Nandwana, NK, Das, S, Nandwana, V, Shareef, MAdil, Das, Y, Saito, M, Weiss, LM, Almaguel, F, Hosmane, NS, Evans, T |
Journal | Molecules |
Volume | 27 |
Issue | 9 |
Date Published | 2022 Apr 19 |
ISSN | 1420-3049 |
Abstract | A standard goal of medicinal chemists has been to discover efficient and potent drug candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. In this review, we collectively represent the current boron-containing drug candidates, boron-containing retinoids, benzoxaboroles, aminoboronic acid, carboranes, and BODIPY, for the treatment of different human diseases.In addition, we also describe the synthesis, key structure-activity relationship, and associated biological activities, such as antimicrobial, antituberculosis, antitumor, antiparasitic, antiprotozoal, anti-inflammatory, antifolate, antidepressant, antiallergic, anesthetic, and anti-Alzheimer's agents, as well as proteasome and lipogenic inhibitors. This compilation could be very useful in the exploration of novel boron-derived compounds against different diseases, with promising efficacy and lesser side effects. |
DOI | 10.3390/molecules27092615 |
Alternate Journal | Molecules |
PubMed ID | 35565972 |
Grant List | R01AI132614-01A1, R21 AA027374-01, 1R01NS109423-01A1 / NH / NIH HHS / United States |