Publications

Manzo OLaura, Nour J, Sasset L, Marino A, Rubinelli L, Palikhe S, Smimmo M, Hu Y, Bucci MRosaria, Borczuk A, Elemento O, Freed JK, Norata GDanilo, Di Lorenzo A. Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis. Circ Res. 2024;.

Rubinelli L, Garcia-Bonilla L, Sasset L, Cantalupo A, Goya B, Ip J, Anrather J, Iadecola C, Faraco G, Di Lorenzo A. Essential Role of Endothelial Sphingolipid Biosynthesis in Cerebrovascular Homeostasis. Circ Res. 2023;.

Sasset L, Manzo OLaura, Zhang Y, Marino A, Rubinelli L, Riemma MAntonietta, Chalasani MLatha S, Dasoveanu DC, Roviezzo F, Jankauskas SS, Santulli G, Bucci MRosaria, Lu TT, Di Lorenzo A. Nogo-A reduces ceramide de novo biosynthesis to protect from heart failure. Cardiovasc Res. 2022;.

Sasset L, Chowdhury KH, Manzo OL, Rubinelli L, Konrad C, Maschek JA, Manfredi G, Holland WL, Di Lorenzo A. S1P controls endothelial sphingolipid homeostasis via ORMDL. FASEB J. 2022;36 Suppl 1.

Sasset L, Chowdhury KH, Manzo OL, Rubinelli L, Konrad C, J Maschek A, Manfredi G, Holland WL, Di Lorenzo A. Sphingosine-1-phosphate controls endothelial sphingolipid homeostasis via ORMDL. EMBO Rep. 2022;:e54689.

Del Gaudio I, Rubinelli L, Sasset L, Wadsack C, Hla T, Di Lorenzo A. Endothelial Spns2 and ApoM Regulation of Vascular Tone and Hypertension Via Sphingosine-1-Phosphate. J Am Heart Assoc. 2021;:e021261.

Aslanidou L, Trachet B, Sasset L, Lovric G, Stergiopulos N, Di Lorenzo A. Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection. J Vasc Res. 2020;:1-9.

Cantalupo A, Sasset L, Gargiulo A, Rubinelli L, Del Gaudio I, Benvenuto D, Wadsack C, Jiang X-C, Bucci MRosaria, Di Lorenzo A. Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide. Hypertension. 2020;:HYPERTENSIONAHA11914507.

Di Lorenzo A. Sphingosine-1-phosphate receptor-1 (S1PR1) signaling: the homeostatic pathway of the heart. Cardiovasc Res. 2020;.

Barry DM, McMillan EA, Kunar B, Lis R, Zhang T, Lu T, Daniel E, Yokoyama M, Gomez-Salinero JM, Sureshbabu A, Cleaver O, Di Lorenzo A, Choi ME, Xiang J, Redmond D, Rabbany SY, Muthukumar T, Rafii S. Molecular determinants of nephron vascular specialization in the kidney. Nat Commun. 2019;10(1):5705.

Gaudino MF, Lorusso R, Ohmes LB, Narula N, McIntire P, Gargiulo A, Bucci MRosaria, Leonard J, Rahouma M, Di Franco A, He G-W, Girardi LN, Tranbaugh RF, Di Lorenzo A. Open radial artery harvesting better preserves endothelial function compared to the endoscopic approach. Interact Cardiovasc Thorac Surg. 2019;.

Marino A, Zhang Y, Rubinelli L, Riemma MAntonietta, Ip JE, Di Lorenzo A. Pressure overload leads to coronary plaque formation, progression, and myocardial events in ApoE-/- mice. JCI Insight. 2019;4(9).

Falzone ME, Rheinberger J, Lee B-C, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A. Structural basis of Ca-dependent activation and lipid transport by a TMEM16 scramblase. Elife. 2019;8.

Farber G, Parks MM, Guahmich NLustgarten, Zhang Y, Monette S, Blanchard SC, Di Lorenzo A, Blobel CP. ADAM10 controls the differentiation of the coronary arterial endothelium. Angiogenesis. 2018;.

Xu R, Yallowitz A, Qin A, Wu Z, Shin DYeon, Kim J-M, Debnath S, Ji G, Bostrom MP, Yang X, Zhang C, Dong H, Kermani P, Lalani S, Li N, Liu Y, Poulos MG, Wach A, Zhang Y, Inoue K, Di Lorenzo A, Zhao B, Butler JM, Shim J-H, Glimcher LH, Greenblatt MB. Targeting skeletal endothelium to ameliorate bone loss. Nat Med. 2018;24(6):823-833.

Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T. An engineered S1P chaperone attenuates hypertension and ischemic injury. Sci Signal. 2017;10(492).

Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension. 2017;70(2):426-434.

Zhang Y, Huang Y, Cantalupo A, Azevedo PS, Siragusa M, Bielawski J, Giordano FJ, Di Lorenzo A. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload. JCI Insight. 2016;1(5).

Christensen PM, Liu CH, Swendeman SL, Obinata H, Qvortrup K, Nielsen LB, Hla T, Di Lorenzo A, Christoffersen C. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. FASEB J. 2016;30(6):2351-9.

Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC. The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Arterioscler Thromb Vasc Biol. 2016;36(2):370-9.

Cantalupo A, Di Lorenzo A. S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. J Pharmacol Exp Ther. 2016;358(2):359-70.

Liu D, Lei L, Desir M, Huang Y, Cleman J, Jiang W, Fernandez-Hernando C, Di Lorenzo A, Sessa WC, Giordano FJ. Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis--Brief Report. Arterioscler Thromb Vasc Biol. 2016;36(3):442-5.

Sasset L, Zhang Y, Dunn TM, Di Lorenzo A. Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. Trends Endocrinol Metab. 2016;27(11):807-819.